Basic Information
VIS ID
TVIS44004737
Fusion event
HTLV-1-FCAR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
55397322/54885910 (Hg38)
End
55397322/54885910 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
FCAR
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-122-3p ; hsa-mir-1281 ; hsa-mir-1915-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4690-3p ; hsa-mir-4722-3p ; hsa-mir-4726-3p ; hsa-mir-5685 ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6764-5p ; hsa-mir-6778-3p
Nearest miRNA
hsa-let-7e/Upstream/240527; hsa-mir-10394/Downstream/237315;
Nearest TSS
ENST00000633603/Upstream/11620; ENST00000594721/Downstream/4763;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/358626, chr19-CpG: 28/Downstream/53544
Upstream sequence
attcaagatttcacattgcggctgggagtggtggctcacgcctgtaatcccaacacttagggaagccgaggcgggtggatcacccaaggtcaggagttcg
Downstream sequence
agaccagcctggccaacatggtgaattccccgtctctactgaaaatgcaacaatCgccgggcgcggtggctcacgcctgtaatcccaacactttgggtgg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate