Basic Information
VIS ID
TVIS44004740
Fusion event
HTLV-1-KIF2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
61607753/62311926 (Hg38)
End
61607753/62311926 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
KIF2A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-183-5p ; hsa-mir-34a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-615-3p ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/2608223; hsa-mir-103a-1/Downstream/9857541;
Nearest TSS
ENST00000502646/Upstream/113; ENST00000509624/Downstream/49380;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/4823, chr5-CpG: 57/Downstream/91597
Upstream sequence
ttccaagtgcttcaagacatgttagctaattggatcttcacaggaactctatgaggtaagcaggatagaaaggtggcagattattggtttataggtgaag
Downstream sequence
aatctgaggttggattatttgccaagatcacatggttaataaggagcatagcctgggccaaagcccgaatcccttcactcccagctctctaagtgctGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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