Basic Information
VIS ID
TVIS44004751
Fusion event
HTLV-1-LMF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1026482/976482 (Hg38)
End
1026482/976482 (Hg38)
Orient
-
Location type
Intronic
Target gene
LMF1
miRNAs that regulate target gene
hsa-mir-935
Nearest miRNA
hsa-mir-3176/Upstream/206205; hsa-mir-11401/Downstream/758503;
Nearest TSS
ENST00000527434/Upstream/5483; ENST00000566034/Downstream/430;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5179, chr16-CpG: 448/Downstream/3396
Nearby gene
SOX8(+5326) ;
Upstream sequence
GTACACGGCACAGCTGTACTGCAGGGTTAGGGACAGGATTTACTGCCACCAACGGAAGCGTTGATTCCAAGTCTCAGACACCGCCCCCAGGCTGGGCCTC
Downstream sequence
CCTCGACGGAAGGTGACGCTCTCTGGGAGGTCCTTGGTGCTCACCTCCCTGGCTGCTTGGGGCCCCAGGGCTCCTGCCTAGGGATGTTTTGGGGCTGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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