Basic Information
VIS ID
TVIS44004769
Fusion event
HTLV-1-chr8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
134311846/133299603 (Hg38)
End
134311846/133299603 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/253022; hsa-mir-10400/Downstream/1500917;
Nearest TSS
ENST00000518652/Upstream/1145; ENST00000561761/Downstream/2419;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1701, chr8-CpG: 249/Downstream/270123
Nearby gene
NDRG1(-2299) ;
Nearest cancer related gene
NDRG1(TSG, -2299) ;
Upstream sequence
GCTCTTATGAGCTGGGTCCTGTACTCCGCCACTGGGAAAGGACTGAAAAGGCAAAAACATTTTCTACAGGTGCATAGCATGGTACAGCCCCAAGACGCAG
Downstream sequence
TTTCTCCATCCATACAGCGTGGTTGAGATGAactcattcattccctaactatattaaggacctactatgcccaggcaccattctagaccctggggacatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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