Basic Information
VIS ID
TVIS44004790
Fusion event
HTLV-1-chr16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9755451/9661594 (Hg38)
End
9755451/9661594 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/4029028; hsa-mir-11401/Downstream/1644846;
Nearest TSS
ENST00000527434/Upstream/119549; ENST00000636913/Downstream/15249;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/568762, chr16-CpG: 282/Downstream/518492
Nearby gene
GRIN2A(-91811) ;
Nearest cancer related gene
GRIN2A(TSG, -91811) ;
Upstream sequence
ACATCTATCTCTGTTTCAAGTCACAGCCGCCCCCACCTTCCGAGTAGATAAAATCAGACTAGTAGTTTGTCTGCAGAAGCAAAGAGGGATTGGGATGTGG
Downstream sequence
GGCGGGGATGGGCCAATCTCAGCCAAATGGGTAATTTATTGCCAGAAGCCCCTGGGATCAAATCAGAACATTGTCTTTAGATCTGCCAGAAAACCACCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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