Basic Information
VIS ID
TVIS44004793
Fusion event
HTLV-1-NBAS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
15580741/15440617 (Hg38)
End
15580741/15440617 (Hg38)
Orient
+
Location type
Intronic
Target gene
NBAS
miRNAs that regulate target gene
hsa-mir-432-5p
Nearest miRNA
hsa-mir-3125/Upstream/2703173; hsa-mir-10b/Downstream/3907812;
Nearest TSS
ENST00000437798/Upstream/16223; ENST00000438178/Downstream/70686;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/804932, chr2-CpG: 27/Downstream/120398
Upstream sequence
tcatcaaaggccaaaagtagataaaaccacaaagatggggaaaaaacagagcagaaaaactggaaactctcaaaagcagagcaactctcctcctccaaag
Downstream sequence
gaacgcagttcctcaccagcaatgggacaaagctggatggagaatgactttgatgagttgagagaaggcttcagatgatccaactactccgagctacagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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