Basic Information
VIS ID
TVIS44004799
Fusion event
HTLV-1-ARIH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
48962456/48925023 (Hg38)
End
48962456/48925023 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARIH2
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-19a-3p ; hsa-mir-93-5p ; hsa-mir-1301-3p ; hsa-mir-342-3p ; hsa-mir-1229-5p ; hsa-mir-1304-5p ; hsa-mir-6134 ; hsa-mir-6769a-5p ; hsa-mir-6806-5p ; hsa-mir-6769b-5p ; hsa-mir-8055 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-7854-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-610 ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-6777-3p ; hsa-mir-5195-5p
Nearest miRNA
hsa-mir-12127/Upstream/280743; hsa-let-7g/Downstream/95125;
Nearest TSS
ENST00000440867/Upstream/307; ENST00000495507/Downstream/1695;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/5518, chr3-CpG: 130/Downstream/64660
Upstream sequence
gacctcgtgatctgcctgcctcggcctcccaaagtgctgggattacaggtgtgagccactgcgcccagcctaatttttgtatttttagtagagatgggat
Downstream sequence
tttgccatgttggctaggctggcctcaatctcctggcctcaggtgatctggccaccttggtctcccaaagtgccgggattttttttctttttttcttttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate