Basic Information
VIS ID
TVIS44004803
Fusion event
HTLV-1-ELOVL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
111011525/110090369 (Hg38)
End
111011525/110090369 (Hg38)
Orient
+
Location type
Intronic
Target gene
ELOVL6
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-106b-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-4531 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-3117-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-218-5p ; hsa-mir-6867-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-541-5p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-196a-3p ; hsa-mir-661 ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-451b ; hsa-mir-508-5p ; hsa-mir-3120-3p ; hsa-mir-7703 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-3187-5p ; hsa-mir-5189-5p ; hsa-mir-4793-3p ; hsa-mir-1285-3p ; hsa-mir-1292-3p ; hsa-mir-1273g-3p ; hsa-mir-4252
Nearest miRNA
hsa-mir-12113/Upstream/601574; hsa-mir-1243/Downstream/770213;
Nearest TSS
ENST00000502981/Upstream/30330; ENST00000510961/Downstream/107997;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/360277, chr4-CpG: 80/Downstream/105937
Upstream sequence
ACTTTTTTTCTGTGGGTTCCTTTTGAGCAGCAAGATTGATAACTAATCATTTACCATTTATCTACATGTAAACCTTCTATACATTAACACAGAAATAAAA
Downstream sequence
GTAGGCACCCTCTATTCATATTTTTGTCAACCATAACCCTTAAAAGATGCAATTTATGCCATCCTCAATAGCATTGTATATGTAAAGAAATCCAGTCATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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