Basic Information
VIS ID
TVIS44004807
Fusion event
HTLV-1-LRRCC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
86045409/85133174 (Hg38)
End
86045409/85133174 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRCC1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-12123/Upstream/4891701; hsa-mir-10400/Downstream/6072311;
Nearest TSS
ENST00000518652/Upstream/24512; ENST00000521234/Downstream/43867;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/25545, chr8-CpG: 113/Downstream/43792
Upstream sequence
gatttctctacttctctcttctccaacctgctctcatctggcttttatctctattgctctactagcattgcgctatcaaagccaccagcaatatccacac
Downstream sequence
tatgaaagttgtgagtcaaatttgtcctcatctgatttgacctaggtgcaggattagacagggttgatagctttctcctcttccatactctttctttgct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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