Basic Information
VIS ID
TVIS44004819
Fusion event
HTLV-1-FGF9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
22245946/21671807 (Hg38)
End
22245946/21671807 (Hg38)
Orient
-
Location type
UTR5
Target gene
FGF9
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-140-5p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-599 ; hsa-mir-5007-3p ; hsa-mir-4662a-5p ; hsa-mir-4480 ; hsa-mir-1279 ; hsa-mir-3941 ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-483-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6881-3p ; hsa-mir-433-3p ; hsa-mir-6895-3p ; hsa-mir-942-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-4264 ; hsa-mir-877-3p ; hsa-mir-622
Nearest miRNA
hsa-mir-4499/Upstream/1237961; hsa-mir-1267/Downstream/2490609;
Nearest TSS
ENST00000623511/Upstream/424; ENST00000461657/Downstream/2195;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/584, chr13-CpG: 190/Downstream/1857
Upstream sequence
CAGTGGTTTGACCTTGAACCTGTGCCAGTGAAACAGCAGATTACTTTTATTTATGCATTTAATGGATTGAAGAAAAGAACCTTTTTTTTCTCTCTCTCTC
Downstream sequence
TGCAACTGCAGTAAGGGAGGGGAGTTGGATATACCTCGCCTAATATCTCCTGGGTTGACACCATCATTATTGTTTATTCTTGTGCTCCAAAAGCCGAGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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