VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004860

Fusion event

HTLV-1-PIK3R1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

q13.1

Reference genome

GRCh37/hg19

Start

67544989/68249161 (Hg38)

End

67544989/68249161 (Hg38)

Orient

Location type

Intronic

Target gene

PIK3R1

miRNAs that regulate target gene

hsa-mir-29a-3p ; hsa-mir-376a-3p ; hsa-mir-29b-3p ; hsa-mir-21-5p ; hsa-let-7a-5p ; hsa-mir-155-5p ; hsa-mir-503-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-646 ; hsa-mir-6838-5p ; hsa-mir-448 ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-190a-3p ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-221-3p ; hsa-mir-1277-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-4793-5p ; hsa-mir-3924 ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-455-5p ; hsa-mir-5580-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-6721-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-542-3p ; hsa-mir-218-1-3p ; hsa-mir-143-3p ; hsa-mir-128-3p ; hsa-mir-487a-3p ; hsa-mir-486-5p ; hsa-mir-1202 ; hsa-mir-126-3p ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-302a-5p ; hsa-mir-3658 ; hsa-mir-3972 ; hsa-mir-4317 ; hsa-mir-4755-3p ; hsa-mir-5006-5p ; hsa-mir-5007-5p ; hsa-mir-7856-5p ; hsa-mir-924

Nearest miRNA

hsa-mir-10397/Upstream/8545458; hsa-mir-103a-1/Downstream/3920306;

Nearest TSS

ENST00000502646/Upstream/9263; ENST00000522084/Downstream/31079;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/32603, chr5-CpG: 26/Downstream/39224

Nearest cancer related gene

PIK3R1(OG, No orient, 0)

Upstream sequence

ACATGAGCATTTTATGTAGGGAGGTTGAAATGCATTGTTATAATCAGGCTGTGTAATTTCCTTCTGTCAAGACCTACCCATTTACCAGTAATGATACCTT

Downstream sequence

CTTTCTCTTCTATTTTTGTCTCTTCCTTTAGGAAAAGGAATATATGCTTACTCATTATTTAAAATTCAGAGTCATTTTCCTGTTCCAGTTGGTTTTGTTC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.