Basic Information
VIS ID
TVIS44004864
Fusion event
HTLV-1-DNAH11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
21644419/21604801 (Hg38)
End
21644419/21604801 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNAH11
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1183/Upstream/133655; hsa-mir-10399/Downstream/4345118;
Nearest TSS
ENST00000635602/Upstream/43710; ENST00000465593/Downstream/13393;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/61106, chr7-CpG: 85/Downstream/340652
Upstream sequence
CTTGTTTGGAATCCCCAAATATAAAGCAGGTTTGTTGTGTTTGAAGAGGGATAAGGGGACCTGAGCTCATGGATGTAACTTCCTCCTGGCTTCCCAGCCA
Downstream sequence
TGGCCTCCGAGGGACTCCATGGAATACTTAGGTTCCATGGAATGGAATTGGAAATGCAAAGTGAGACTCTGTCTGTACAGAGGGCGGATGCAGAGTTTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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