Basic Information
VIS ID
TVIS44004868
Fusion event
HTLV-1-NOL8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
95086602/92324320 (Hg38)
End
95086602/92324320 (Hg38)
Orient
+
Location type
Intronic
Target gene
NOL8
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-186-5p ; hsa-mir-1260b
Nearest miRNA
hsa-mir-101-2/Upstream/31773; hsa-let-7a-1/Downstream/203664;
Nearest TSS
ENST00000422679/Upstream/159; ENST00000618653/Downstream/340;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/30303, chr9-CpG: 64/Downstream/1347
Upstream sequence
GAAGAGTTCTTTCCCTTAGTTCTTCTAAAATCTAACAAAACAACTACTTCCTCTGAACCTTCTGTATCAAATCCGTCTCCTGGATCTGTATTTCACTTCC
Downstream sequence
TATTGTATTACTTCCAAATTTTAGTCTTCGAGGTTTTGCCCAAGCCCTACATCCACATCTTTCATGAATGCACTTTGGAACAGCAACCCCATACCCATAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate