Basic Information
VIS ID
TVIS44004883
Fusion event
HTLV-1-CYP7B1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
65687920/64775363 (Hg38)
End
65687920/64775363 (Hg38)
Orient
-
Location type
Intronic
Target gene
CYP7B1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1273e ; hsa-mir-7847-3p ; hsa-mir-219b-3p ; hsa-mir-4795-5p ; hsa-mir-6840-3p ; hsa-mir-302f ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-1915-3p ; hsa-mir-6764-5p ; hsa-mir-17-5p ; hsa-mir-3160-3p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4487 ; hsa-mir-455-3p ; hsa-mir-558 ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6851-5p ; hsa-mir-1296-5p ; hsa-mir-4512 ; hsa-mir-6895-5p ; hsa-mir-7160-3p
Nearest miRNA
hsa-mir-124-1/Upstream/396106; hsa-mir-10400/Downstream/9773180;
Nearest TSS
ENST00000518652/Upstream/159549; ENST00000523170/Downstream/23398;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/189092, chr8-CpG: 73/Downstream/23033
Upstream sequence
GTGAGTCTTGAAACTATTGTTCTTGTTTGACAGGCAGTCTAAGAGGAATTCCAAATAACCACCTTAGCTCCAACTAAAGTGGAGCCAATGAGTTATATTC
Downstream sequence
CTTATAGTAAACTGTGTATTCTCAGGTTTCTCGGCATTTTGGGAACTAATAATGACTATAAAGAAAATAGTCCACAGGCTTTGTTTTCCATGTTATGATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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