Basic Information
VIS ID
TVIS44004887
Fusion event
HTLV-1-PCCA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
101169761/100517507 (Hg38)
End
101169761/100517507 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
PCCA
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-455-5p ; hsa-mir-7152-5p ; hsa-mir-568 ; hsa-mir-1273e ; hsa-mir-155-5p ; hsa-mir-4326 ; hsa-mir-15b-3p ; hsa-mir-486-5p
Nearest miRNA
hsa-mir-1297/Upstream/874358; hsa-mir-1267/Downstream/1450135;
Nearest TSS
ENST00000623511/Upstream/2080; ENST00000624456/Downstream/16146;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/427956, chr13-CpG: 51/Downstream/14635
Upstream sequence
AAGGCATTTCGTAAATGGGAACAATGTGATATCAGTCCTTGGTTCATTGATGTAGCTCAGATATTAAAAACACCCACCAATAATTAAATGTGTGTACTCA
Downstream sequence
TTAAGAATGGTTTGAGAACTGTTAAAAATATGTTACGGCAGAGCAACGGGGCCTATATTTTATGCATTCCTTTAAATTCAGAGTACCTGGGGGGCACGCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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