Basic Information
VIS ID
TVIS44004889
Fusion event
HTLV-1-ACIN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
23555657/23086448 (Hg38)
End
23555657/23086448 (Hg38)
Orient
-
Location type
Intronic
Target gene
ACIN1
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-93-5p ; hsa-mir-18a-5p ; hsa-mir-1226-3p ; hsa-mir-93-3p ; hsa-mir-324-5p ; hsa-mir-106b-5p ; hsa-mir-221-3p ; hsa-mir-218-5p ; hsa-mir-7108-5p ; hsa-mir-1227-5p ; hsa-mir-3187-3p ; hsa-mir-663b ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-6877-5p ; hsa-mir-4529-5p ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-4640-3p
Nearest miRNA
hsa-mir-4707/Upstream/129419; hsa-mir-1185-1/Downstream/302148;
Nearest TSS
ENST00000550708/Upstream/6855; ENST00000554203/Downstream/8317;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/28297, chr14-CpG: 78/Downstream/8321
Upstream sequence
AGCTCTTTTTGAAAAAATTAAGGACGGTAAGAATTTCTGTACACACAGTCATGATATAGAAGGAAATTCAGACAATTTATGACTATGGTAGGTGGATAAT
Downstream sequence
GAGTCCTAACACCTTAGAAATATCTGAAGAAAGTGATGGAGACATAAGAGGGAAAGTCAGACAGGATTTTATAAACCAAttatttctttgagacatggtt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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