Basic Information
VIS ID
TVIS44004894
Fusion event
HTLV-1-SEMA6C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
151104485/151132009 (Hg38)
End
151104485/151132009 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA1F
Target gene
SEMA6C
Nearest miRNA
hsa-mir-101-1/Upstream/579995; hsa-mir-1182/Downstream/413787;
Nearest TSS
ENST00000473358/Upstream/38763; ENST00000368910/Downstream/859;
Nearest CpG islands
chr1-CpG: 206/Target, None/Upstream, None/Downstream
Upstream sequence
ACCTTTCCAGACTGCCCCCCGGCGGGACCGCAGCCATCCCATTACCCGGGAGAGCCCAGGGCCCAGATGAAGGCAGAGAGCGAGGGCGCCCAGAGCGAGC
Downstream sequence
CGACCGACTGCCGCCCTCCCCCGCCCGAGTGAAGTCAGGCAGTGGCTGCAGACACGGCTGTATTGGGAAGCGGAGGCTCCTACACAGTAGGAGAGGCACG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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