Basic Information
VIS ID
TVIS44004928
Fusion event
HTLV-1-chr18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
45693225/48166854 (Hg38)
End
45693225/48166854 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372104 ; ZBTB7C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-106b-3p ; hsa-mir-1228-3p ; hsa-mir-8485 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-510-5p
Nearest miRNA
hsa-mir-1-2/Upstream/786289; hsa-mir-122/Downstream/503746;
Nearest TSS
ENST00000575820/Upstream/1288; ENST00000591412/Downstream/36747;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/4713, chr18-CpG: 262/Downstream/241228
Nearby gene
ZBTB7C(-29545) ;
Nearest cancer related gene
ZBTB7C(TSG, No orient, 0)
Upstream sequence
GTAGATGGACCATATTGGGCACATTTGGTGATGGTTTTGCTGAAGTGTGCCTGGAAGCTGCTGTCCACACTGGAACAAGCCTCTGGCACCTATTGGGCAC
Downstream sequence
CTCCTAAGCTAGAAGGTGGCTCAGTTGTGTTGTCCTTACTGGCGGGGGGGAAGCTCTTGAGGCTGTTTCCCCACTCACAGCCCCCAGCCCCAGGAAGAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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