Basic Information
VIS ID
TVIS44004944
Fusion event
HTLV-1-AFDN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
168339378/167938698 (Hg38)
End
168339378/167938698 (Hg38)
Orient
+
Location type
Intronic
Target gene
AFDN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-346 ; hsa-mir-15b-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-10398/Upstream/940786; hsa-mir-4644/Downstream/2392063;
Nearest TSS
ENST00000381078/Upstream/6096; ENST00000509296/Downstream/9331;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/110819, chr6-CpG: 17/Downstream/13138
Nearest cancer related gene
AFDN(OG, No orient, 0)
Upstream sequence
TTCTATTGCATATAGTATGATAAATTACCTACCTTAAAATGGTAGAGGATTTCGGGTTCTTTAAATGCCATGTGCTGTTCATGTGGAGTCCACATGTTCA
Downstream sequence
GCTTGCACGTTGGCTGTCTGCTTGTATAGGGTGGCTAGGAAGGAAAAGAGCCTAGTGGTTGCCCTCAGGTATGTGATTACTGCTCTGAATGAAGGAGTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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