Basic Information
VIS ID
TVIS44004948
Fusion event
HTLV-1-EDA2R integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65836920/66617078 (Hg38)
End
65836920/66617078 (Hg38)
Orient
-
Location type
Intronic
Target gene
EDA2R
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-7113-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-3911 ; hsa-mir-7847-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4524a-3p ; hsa-mir-4302 ; hsa-mir-6760-5p ; hsa-mir-4779 ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-297 ; hsa-mir-6867-5p ; hsa-mir-3924 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-4711-3p ; hsa-mir-4796-5p
Nearest miRNA
hsa-let-7f-2/Upstream/598099; hsa-mir-105-1/Downstream/3405779;
Nearest TSS
ENST00000429181/Upstream/1048; ENST00000513847/Downstream/21963;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/794616, chrX-CpG: 27/Downstream/926885
Nearest cancer related gene
EDA2R(TSG, No orient, 0)
Upstream sequence
GGTTGTCTTCTACAAAGAGGAATTTTAATGAAGGGGCTAAAGTAATTCATAAATGGGGCTTATCCTACTCAAAGAGAAAGGTAGCATGAGGTTCTTTACT
Downstream sequence
TACTCATGACTTCATACTAGGGTGAATTTCAAGTGGTTTCTAAAAGTGCCAAAGTCCTAAATGTGTACTCTTAGTCAGAAGAGACGAGAGTGTACATGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate