Basic Information
VIS ID
TVIS44004956
Fusion event
HTLV-1-DOCK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
129093290/127295026 (Hg38)
End
129093290/127295026 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
DOCK1
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-183-5p ; hsa-mir-155-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-6867-5p ; hsa-mir-31-5p
Nearest miRNA
hsa-mir-107/Upstream/1475204; hsa-mir-202/Downstream/2548273;
Nearest TSS
ENST00000439456/Upstream/46958; ENST00000398023/Downstream/254343;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/98461, chr10-CpG: 18/Downstream/102006
Upstream sequence
ccaccacacctggccAAGTTGTCCTATTCTTAAATAAGGATAGCACATATAGAATTATTATGGGGATTCAGGtgtaaccccagggctttgggaggcctag
Downstream sequence
gtgggaggatcacttgatgccaggaatttaagttttcagcctgggcaacaaagtgaaaccccttctgtgagtccattttgtgttgctctagaggaatacc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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