Basic Information
VIS ID
TVIS44004971
Fusion event
HTLV-1-JAKMIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
6185819/6184092 (Hg38)
End
6185819/6184092 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
JAKMIP1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-378d-1/Upstream/260764; hsa-mir-12113/Downstream/1126358;
Nearest TSS
ENST00000502981/Upstream/33584; ENST00000507424/Downstream/10525;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/71119, chr4-CpG: 169/Downstream/15093
Upstream sequence
GAAAGTTGAATTCATCAGAGCAACCTCACTGTCCTCACTGACTGACCTTATAACTGGTAAATGTTGTCAGTTTAAAGTCATAAGATAAATGTGAGAATAA
Downstream sequence
ACCATCACTTCTCTGTTTTGTATATTGGAGCAGGGTGGTTTAGCTATGTAAAAATTTTATTTTTGAAAAGActtcattttgcagatgggaaaacaaaccc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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