Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene392752291630351355290008300044336087342465311466314268316370318580326986328930304415306268306393307878309320310270322886323668321401321800319799320052321181321330332881333030330181330320304014304108341380
Basic Information
VIS ID
TVIS44004973
Fusion event
HTLV-1-DUSP22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
341380/341380 (Hg38)
End
341380/341380 (Hg38)
Orient
+
Location type
Intronic
Target gene
DUSP22
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-4664-3p ; hsa-mir-1180-3p ; hsa-mir-4497 ; hsa-mir-139-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4691-3p ; hsa-mir-449b-3p ; hsa-mir-6856-3p
Nearest miRNA
hsa-mir-10398/Downstream/1048934;
Nearest TSS
ENST00000381078/Upstream/3374; ENST00000469834/Downstream/50359;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/48541, chr6-CpG: 261/Downstream/49808
Nearest cancer related gene
DUSP22(TSG, No orient, 0)
Upstream sequence
AAACGGAGAGCAGGAACAGGGAACTTGTGTTCATCGAAACAGCTTGCGGTAGGATAGTGCTTCAGACTCGCACTTCTGCTTCTAACTGCAGTTGAGCAAT
Downstream sequence
AGAAGGACCAGGACTGTGGGTATTTCCCACTGTGGAGGAGGGAGTTTAATGACCAGAGTTGGGGCTTCTGTCATCAGCTTCCCTGGAAATAACACCCCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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