Basic Information
VIS ID
TVIS44004978
Fusion event
HTLV-1-ABCA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
139920539/137026087 (Hg38)
End
139920539/137026087 (Hg38)
Orient
+
Location type
Intronic
Target gene
ABCA2
miRNAs that regulate target gene
hsa-mir-19b-3p ; hsa-mir-485-5p ; hsa-mir-4644 ; hsa-mir-218-1-3p ; hsa-mir-6721-5p ; hsa-mir-4722-5p ; hsa-mir-6089 ; hsa-mir-7112-5p ; hsa-mir-4768-3p ; hsa-mir-320e ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-let-7a-1/Upstream/139284; hsa-mir-3621/Downstream/143099;
Nearest TSS
ENST00000422679/Upstream/5282; ENST00000457302/Downstream/1377;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3047, chr9-CpG: 182/Downstream/1658
Upstream sequence
GGAGGCCTAGATGCCTTCTCTGGGCATGACCCCTCCCTGTAGCTCCCGCCTACTGTGTCGGGGGGAGAACAGGTGAGACCCGAGGGTGGCGCTGCCATCT
Downstream sequence
GCCATCCCAGTGACTTCATGACAGTGACCCTGTCCCTGCACCAAGAGCAGCCTGTAGCCCAAGGGTAGACCCAAGTCCAGCTAACTAAGAGGAGATAGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate