Basic Information
VIS ID
TVIS44004982
Fusion event
HTLV-1-GALNT7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.1
Reference genome
GRCh37/hg19
Start
174108192/173187041 (Hg38)
End
174108192/173187041 (Hg38)
Orient
+
Location type
Intronic
Target gene
GALNT7
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-378a-3p ; hsa-mir-214-3p ; hsa-mir-374b-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-17-3p ; hsa-mir-154-5p ; hsa-mir-125b-2-3p ; hsa-mir-4731-3p ; hsa-mir-4801 ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-660-5p ; hsa-mir-548k ; hsa-mir-4282 ; hsa-mir-3973 ; hsa-mir-219b-3p ; hsa-mir-5591-3p ; hsa-mir-548av-5p ; hsa-mir-8054 ; hsa-mir-5700 ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-34a-5p ; hsa-mir-552-5p ; hsa-mir-4666a-5p ; hsa-mir-374a-5p ; hsa-mir-8064
Nearest miRNA
hsa-mir-12113/Upstream/2000749; hsa-mir-1305/Downstream/81119;
Nearest TSS
ENST00000502981/Upstream/17389; ENST00000502407/Downstream/95394;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/16769, chr4-CpG: 158/Downstream/146491
Upstream sequence
tttttagtagagacggatgttggccaggatggtctcgatctcctgacctcgtgatccacccgcctcggccgcccaaagtgctggaattacaggtgtgagc
Downstream sequence
caccgcacccggccTACTTACTTTTAAAATACATTTACATTAAGAAaaaaagaatgtatgttcattgtagaaaatattacaaagttaaagcaagtaagaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate