Basic Information
VIS ID
TVIS44004983
Fusion event
HTLV-1-DNAJC6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
65866615/65400932 (Hg38)
End
65866615/65400932 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
DNAJC6
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-4260 ; hsa-mir-1227-5p ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-6867-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p
Nearest miRNA
hsa-mir-101-1/Upstream/342424; hsa-mir-11399/Downstream/1227508;
Nearest TSS
ENST00000473358/Upstream/16846; ENST00000497874/Downstream/19655;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/90869, chr1-CpG: 80/Downstream/19241
Upstream sequence
ttggatatatacccagtagcaggattgataaatcatatggcagttctatttttaatattttaaggaatctccaaattgtttcccataatggctgtactaa
Downstream sequence
tttacattcccaccaactgtgtccttttttctctacatccttgccaacatgttttttgttttttttaatagcaattctgacaggagtgaggtgatatgtc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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