Basic Information
VIS ID
TVIS44004993
Fusion event
HTLV-1-PIEZO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
10802145/10802147 (Hg38)
End
10802145/10802147 (Hg38)
Orient
-
Location type
Intronic
Target gene
PIEZO2
Nearest miRNA
hsa-mir-3976/Upstream/42498; hsa-mir-1-2/Downstream/852738;
Nearest TSS
ENST00000575820/Upstream/10497; ENST00000579321/Downstream/53289;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/75478, chr18-CpG: 169/Downstream/346161
Upstream sequence
tgcactccagcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaagaaagaaaaGAAAAGAAAAATTGATTTGTAATGTGGTTAGA
Downstream sequence
GATTATTTTAAGATTTGCATACTGTCTACAACAAAATGATTATTATATGACTCTACTTTTTAACTAGTAATACATTACTACCAGGTGATTTGGGCTTCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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