Basic Information
VIS ID
TVIS44004996
Fusion event
HTLV-1-PEPD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
33954090/33463184 (Hg38)
End
33954090/33463184 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PEPD
miRNAs that regulate target gene
hsa-mir-423-3p
Nearest miRNA
hsa-mir-10395/Upstream/13063830; hsa-let-7e/Downstream/1659516;
Nearest TSS
ENST00000633603/Upstream/68036; ENST00000589967/Downstream/14900;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/61310, chr19-CpG: 56/Downstream/58181
Upstream sequence
CAGTAACACAGCGTGATAAATAACATACAGCACTTCTTCAAAAGCACCTCTTCTTTAAAAAGGAAAAAAAGAATGATATGTGCATGCAGTGGTACAGACA
Downstream sequence
TGTGACAAATTAGAACTTTTTAAAAGCTCCAAAATCCATACAGTTTATTTAAACTGCTATGAAGCACTTCCATTTGGAAGCCGATAAATGCCATGCCTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate