Basic Information
VIS ID
TVIS44005000
Fusion event
HTLV-1-ZSWIM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
44504912/45876273 (Hg38)
End
44504912/45876273 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZSWIM3
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/171093; hsa-mir-1-1/Downstream/1290694;
Nearest TSS
ENST00000382410/Upstream/18656; ENST00000372520/Downstream/4954;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/35345, chr20-CpG: 145/Downstream/13985
Upstream sequence
ctgggactacaggcatgcactaccatgcccggctaattttgtatttttagtagagtcggggtttctccatgttggtagtcaggctggtcttcaactcctg
Downstream sequence
acctctggtgatccgcccatctcggtctcccaaagtgctgggattacaggtgtgagccaccgcgcccagcTGtttgtttttttgagatagggtctcactc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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