Basic Information
VIS ID
TVIS44005001
Fusion event
HTLV-1-SLC25A20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
48920080/48882647 (Hg38)
End
48920080/48882647 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC25A20
miRNAs that regulate target gene
hsa-mir-7856-5p ; hsa-mir-3658 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-3156-5p
Nearest miRNA
hsa-mir-12127/Upstream/238367; hsa-let-7g/Downstream/137501;
Nearest TSS
ENST00000440867/Upstream/23979; ENST00000463738/Downstream/16245;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/34674, chr3-CpG: 41/Downstream/15961
Upstream sequence
CTACCTTATAAAAGAAATACGAAAAACTggtcaggtgtggtggcttacacctgtaatcctagcactgtgggaggccaaggcaagagaattgcttggctcc
Downstream sequence
aggagttcaagaccagcctgggcaagataatgagagcaccccccgccgccccgacacacacacaccgaccattgctaaaaaaaatttaaaaattagccca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate