Basic Information
VIS ID
TVIS44005007
Fusion event
HTLV-1-MCTP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
94071284/94735579 (Hg38)
End
94071284/94735579 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
MCTP1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-4446-5p ; hsa-mir-510-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6505-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-642a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/1114791; hsa-mir-103a-1/Downstream/1343559;
Nearest TSS
ENST00000502646/Upstream/24886; ENST00000513849/Downstream/49318;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/116441, chr5-CpG: 161/Downstream/548176
Upstream sequence
atgcccaggctggtcttgaacttccaggctcaagagatctccttatctcagcctcctaaagcgctgggattataggcatgagccactgtgttgggccTAC
Downstream sequence
ATTATGTTTCAGATTAAGTGATATTCATTTTGATTTACAGGATAGAGTACATAATATACATAAGAGAACAGTTTCACTCTATATAAATAGCCAAACCAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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