Basic Information
VIS ID
TVIS44005016
Fusion event
HTLV-1-CA10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
49905036/51827676 (Hg38)
End
49905036/51827676 (Hg38)
Orient
-
Location type
Intronic
Target gene
CA10
miRNAs that regulate target gene
hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10226/Upstream/1058946; hsa-mir-1250/Downstream/5063594;
Nearest TSS
ENST00000595228/Upstream/79132; ENST00000572848/Downstream/330387;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/566454, chr17-CpG: 89/Downstream/330139
Upstream sequence
ACTAGCTAACAGCATACACAGTGTCTATATATTTATTTCATGATTGCATTAAAGTAGCTATAGATGATTAATCTCTTGCTGGCAGGTAATCGTTACTAGT
Downstream sequence
CCCATCTTTAGACATAGAGTTAACACATCCTATGGGCTCTGTGAGTACTTGGTGGTTGAGGAGGCTCtgtggcacagactggctagctctttaccaagcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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