Basic Information
VIS ID
TVIS44005020
Fusion event
HTLV-1-SOX5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24152169/23999235 (Hg38)
End
24152169/23999235 (Hg38)
Orient
-
Location type
Intronic
Target gene
SOX5
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-194-5p ; hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-96-5p ; hsa-mir-130a-3p ; hsa-mir-181a-5p ; hsa-mir-132-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-1231 ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-4766-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-574-5p ; hsa-mir-5580-3p ; hsa-mir-555 ; hsa-mir-374a-3p ; hsa-mir-136-3p ; hsa-mir-4704-5p ; hsa-mir-3529-3p ; hsa-mir-6759-5p ; hsa-mir-6793-5p ; hsa-mir-6748-5p ; hsa-mir-933 ; hsa-mir-4783-5p ; hsa-mir-3607-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/6325841; hsa-let-7i/Downstream/213186;
Nearest TSS
ENST00000382841/Upstream/48203; ENST00000540733/Downstream/224036;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1373956, chr12-CpG: 92/Downstream/562787
Upstream sequence
gactctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaccattgcttctcttaagtgatttaaaagacaactgcctgctacgtgatctcacttat
Downstream sequence
atgtagtatctttaaaaaaatgaatgcttagaagcagggagtaaaactgtggttaccaatggtgaagggggttgaaagaattgaggagattttgaccaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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