Basic Information
VIS ID
TVIS44005025
Fusion event
HTLV-1-MDGA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
48047694/47578491 (Hg38)
End
48047694/47578491 (Hg38)
Orient
+
Location type
Intronic
Target gene
MDGA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p
Nearest miRNA
hsa-mir-208a/Upstream/10626100; hsa-mir-1185-1/Downstream/182504;
Nearest TSS
ENST00000550708/Upstream/235257; ENST00000557531/Downstream/48034;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/926535, chr14-CpG: 186/Downstream/95739
Upstream sequence
tgtatcttggaacttaaagtaaaataaaaaatttaaaaaaaGAAATAAACTGCTTGAGCAAAATGATGTCCCAATACACAATGTCCCAAAAGTATGGTGA
Downstream sequence
ATTTCCATCTTACTCTATGGAAATTATCAAAATCTAAATTCAGTTCCCCAGCCAAGCAATGACGATAGTGAGACATCACCAAAATAGGGCAAAATTAAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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