Basic Information
VIS ID
TVIS44005057
Fusion event
HTLV-1-CBFA2T3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
88955896/88889488 (Hg38)
End
88955896/88889488 (Hg38)
Orient
+
Location type
Intronic
Target gene
CBFA2T3
miRNAs that regulate target gene
hsa-mir-1273e ; hsa-mir-4709-3p ; hsa-mir-937-3p ; hsa-mir-6755-3p ; hsa-mir-15b-3p ; hsa-mir-4635 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p
Nearest miRNA
hsa-mir-11401/Upstream/173151;
Nearest TSS
ENST00000527434/Upstream/6216; ENST00000378347/Downstream/13027;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/2451, chr16-CpG: 41/Downstream/212
Nearest cancer related gene
CBFA2T3(TSG, No orient, 0)
Upstream sequence
agcagaggaggcaggggcgggagggagggagcgagggtgggaACAGAGGTGGGTGTGATGTGGGGTCCCCTTGGGGAGGGACTGAGGGGAATGAGGGTCT
Downstream sequence
GACCCTGTAAgtgccctgggacgaccagggcgtttggaatttgacagacctaggtttgagccctggcgccctctctccactacctggggggaacccagag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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