Basic Information
VIS ID
TVIS44005058
Fusion event
HTLV-1-TPGS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
511034/511034 (Hg38)
End
511034/511034 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
TPGS1
miRNAs that regulate target gene
hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-1250-5p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-5193 ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-4252 ; hsa-mir-6776-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6742-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-6501-3p ; hsa-mir-508-5p ; hsa-mir-3675-3p ; hsa-mir-3974 ; hsa-mir-4293 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4684-5p ; hsa-mir-4768-3p ; hsa-mir-548c-3p ; hsa-mir-624-3p ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-1302-11/Upstream/438924; hsa-let-7e/Downstream/293906;
Nearest TSS
ENST00000633603/Upstream/3201; ENST00000586788/Downstream/20678;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2955, chr19-CpG: 137/Downstream/7813
Upstream sequence
caaccacagatgtcccagacaccgcccggcgtctgctgggggCAGGAGTGGGAAGCAGAAGTCTAAGGTGTAGGGTGGCTCCTGTCTCTTTCTGGAGACG
Downstream sequence
TTCCATAAATAGAATCTTTCCTGTATTAACAAATGCTCACACGCCTTACAAACCGCTCTGTGTAGGAGCCGACACAGACGGAGCCCTGGCTGGGCTCCCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate