Basic Information
VIS ID
TVIS44005062
Fusion event
HTLV-1-THADA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
43700079/43472940 (Hg38)
End
43700079/43472940 (Hg38)
Orient
-
Location type
Intronic
Target gene
THADA
miRNAs that regulate target gene
hsa-mir-505-3p ; hsa-mir-106b-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1301/Upstream/8001454; hsa-mir-10b/Downstream/3904735;
Nearest TSS
ENST00000437798/Upstream/9681; ENST00000460356/Downstream/13732;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/245128, chr2-CpG: 42/Downstream/122849
Upstream sequence
caatactaacacagtaagtatatgtgtatctaaacatactaagcatagaaaaagaataaaatatgctataagagataaaaaaaaatggcacacctgtcta
Downstream sequence
gggcagttaccacgaatggagcctgcaggactggaagttgttctggggtgagtcagagtgagtggtgggtgaacatgaaggcctagaacactgctgtaca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate