Basic Information
VIS ID
TVIS44005081
Fusion event
HTLV-1-PARM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
75930937/75005727 (Hg38)
End
75930937/75005727 (Hg38)
Orient
-
Location type
Intronic
Target gene
PARM1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-377-3p ; hsa-mir-382-5p ; hsa-mir-4645-3p ; hsa-mir-545-5p ; hsa-mir-1324 ; hsa-mir-6856-3p ; hsa-mir-4422 ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-12113/Upstream/8728799; hsa-mir-1243/Downstream/1567841;
Nearest TSS
ENST00000502981/Upstream/35365; ENST00000512043/Downstream/29097;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/71006, chr4-CpG: 56/Downstream/508498
Nearest cancer related gene
PARM1(OG, No orient, 0)
Upstream sequence
ggaccaagccaaacactagctcttttaaatatcaaatggatgtaaactataatagtggtctccccatagaggacaatacacgtggaAACATATAGTTTTC
Downstream sequence
TATCCAACCAAGAATCTGGTTTTCTTCAGAGAAACAATCCGTCAGCTATTCTTGCAGCAAAAAAGCTTGAACCTGACCAGACTTCAGGAACCACTGCTAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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