Basic Information
VIS ID
TVIS44005084
Fusion event
HTLV-1-CXXC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
105409593/104488436 (Hg38)
End
105409593/104488436 (Hg38)
Orient
+
Location type
Intronic
Target gene
CXXC4
miRNAs that regulate target gene
hsa-mir-30b-3p ; hsa-mir-4695-3p ; hsa-mir-203a-3p ; hsa-mir-4797-3p ; hsa-mir-4264 ; hsa-mir-4302 ; hsa-mir-6733-3p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-4635 ; hsa-mir-570-3p
Nearest miRNA
hsa-mir-12113/Upstream/3158022; hsa-mir-1243/Downstream/5000262;
Nearest TSS
ENST00000502981/Upstream/13178; ENST00000508358/Downstream/2529;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/768796, chr4-CpG: 88/Downstream/657603
Nearest cancer related gene
CXXC4(TSG, No orient, 0)
Upstream sequence
CCCTGTCACTCTGACATGTGCTCAGCTGGTTTCCTACAACCATAACTGTGTATTTGCACATAGGTCTAAGGCAGTCATGATGGCATTGTCTTTTTTAATG
Downstream sequence
ATCTAGATAGGATCTTATACAATTTTGAAAAAAAGCTTTTTATTTCTTTTAGCCAAATAGTATTCCGCTAATAATCTTAGCCTTGAAACACAGCCCATGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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