Basic Information
VIS ID
TVIS44005106
Fusion event
HTLV-1-LOC105375721 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
118701523/117689284 (Hg38)
End
118701523/117689284 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105375721
Nearest miRNA
hsa-mir-12123/Upstream/814484; hsa-mir-10400/Downstream/1635887;
Nearest TSS
ENST00000518652/Upstream/158920; ENST00000366457/Downstream/421130;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/168212, chr8-CpG: 76/Downstream/422451
Nearby gene
EXT1(-110079) ;
Upstream sequence
aatgtggaaaataagtcccagagCATGGTAACATGGCCATAACAGGCCTTGTAGCATTCTGGAATTTAAAAGGCTAGGTGCATAGAAGGGAAAATAGATA
Downstream sequence
CGAATGGCAAAGGCAGGTACATAATGCCTAAAACCAGGATGTGGTGTAGCAGTTACcatcgtcatcatcatcatcatcaCAATGACAATCAATGGTAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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