Basic Information
VIS ID
TVIS44005107
Fusion event
HTLV-1-TRPM3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
73246401/70631485 (Hg38)
End
73246401/70631485 (Hg38)
Orient
+
Location type
Intronic
Target gene
TRPM3
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-4433b-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-6778-3p ; hsa-mir-532-3p ; hsa-mir-1281 ; hsa-mir-1224-3p ; hsa-mir-6814-5p ; hsa-mir-4761-5p
Nearest miRNA
hsa-mir-101-2/Upstream/29397650; hsa-let-7a-1/Downstream/178490;
Nearest TSS
ENST00000422679/Upstream/216861; ENST00000436491/Downstream/76562;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/211176, chr9-CpG: 50/Downstream/815112
Upstream sequence
GAAAAGCTCTGGGTCTTAATTCCCATGTAAATGAACTTTAAATTATCATAATTTCACCACTACTTCCACATAACACTCAAATAGCATCCTCTTTTGGTGG
Downstream sequence
GGAAGGATAGTATAGGTAATTTGAAGTATTAGCACATTTAAGAAAGGAAAAAACTACTTTAAAACGTACAGAGGCACAAAGTGAGCAGACAGCTACTAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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