VISDB - VIS Detail

Basic Information

VIS ID

TVIS44005121

Fusion event

HTLV-1-DGKH integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr13

Cytoband

q14.11

Reference genome

GRCh37/hg19

Start

42629392/42055256 (Hg38)

End

42629392/42055256 (Hg38)

Orient

Location type

Intronic

Target gene

DGKH

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-3935 ; hsa-mir-656-3p ; hsa-mir-577 ; hsa-mir-1277-5p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p ; hsa-mir-4798-3p ; hsa-mir-889-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-545-5p ; hsa-mir-3163 ; hsa-mir-4709-5p ; hsa-mir-4282 ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-568 ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-5011-5p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-1305 ; hsa-mir-6794-3p ; hsa-mir-766-5p ; hsa-mir-4778-3p ; hsa-mir-1304-3p ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-1207-3p ; hsa-mir-4639-3p ; hsa-mir-3161 ; hsa-mir-6804-5p ; hsa-mir-513b-5p ; hsa-mir-4457 ; hsa-mir-125b-2-3p ; hsa-mir-3614-3p ; hsa-mir-6873-5p ; hsa-mir-5680 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p

Nearest miRNA

hsa-mir-2276/Upstream/486861; hsa-mir-1267/Downstream/2140873;

Nearest TSS

ENST00000623511/Upstream/6434; ENST00000489851/Downstream/82786;

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/5832, chr13-CpG: 84/Downstream/216461

Upstream sequence

ggcacctATGTTAGAAAATGGAAGGTAGTATAGTTAGGTTTGCCAAGCATTGCAAAGTTAAGGTGCTGTTAAATATGATCCACATTTAAGGGACCAAATA

Downstream sequence

AAGCTAGATTTCAGTCCATTTAAAAAATCTAATCTTTGTAGAACATTTTATTTTTAGCTTGGTTTGCGTCTTTGCTTCCATTTTAATGTGAACTAAATAT

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.