Basic Information
VIS ID
TVIS44005125
Fusion event
HTLV-1-SNHG14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
25261580/25016433 (Hg38)
End
25261580/25016433 (Hg38)
Orient
+
Location type
Intronic
Target gene
SNHG14
Nearest miRNA
hsa-mir-1268a/Upstream/1454302; hsa-mir-10393/Downstream/832314;
Nearest TSS
ENST00000557528/Upstream/61399; ENST00000552334/Downstream/15440;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/60526, chr15-CpG: 143/Downstream/421815
Nearby gene
SNORD109A(+25541) ;
Upstream sequence
ATGGAATTAGGGAACAAGAATAAATATAATAGGAAGTGTGGTATGCATGTAAGCATGTTTGTGTGTGTATGTGTATATAGGTTGATGCAAGAGTGGAAGG
Downstream sequence
GTAGTAAGGACAAAAACTTTGGACAGCTATATTGACAATGCAAAATAAAAACATGAATGTATGAATGTATGAATTTGACGGATATGTGCTTGAAAGAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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