Basic Information
VIS ID
TVIS44005127
Fusion event
HTLV-1-NEO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
73470802/73178461 (Hg38)
End
73470802/73178461 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEO1
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-32-5p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-183-5p ; hsa-mir-18a-5p ; hsa-mir-6793-3p ; hsa-mir-4775 ; hsa-mir-6771-3p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-10393/Upstream/591148; hsa-mir-11181/Downstream/121449;
Nearest TSS
ENST00000557528/Upstream/42476; ENST00000560407/Downstream/43232;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/125433, chr15-CpG: 29/Downstream/140371
Upstream sequence
AGTGCATTGCTGAAAATGATGTTGGAAATGCACAAGCTGGAGCCCAACTGATAATCCTTGAACATGGTAAGAAGGGCTGAAATAGTCAGATGATAGAGGC
Downstream sequence
TGTGTGCTTGATGAACAAGCACCCATCCGTCCAAATAACTCATGATTGATAACCCATTAGTAAAGGCCAATATGTGGCATAGCTAAGAGAAAAAGAATAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate