Basic Information
VIS ID
TVIS44005135
Fusion event
HTLV-1-MBD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
148835999/148078430 (Hg38)
End
148835999/148078430 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2K
Target gene
MBD5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7151-5p ; hsa-mir-6796-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-3201 ; hsa-mir-429 ; hsa-mir-4314 ; hsa-mir-4502 ; hsa-mir-4738-3p ; hsa-mir-4790-3p ; hsa-mir-4791 ; hsa-mir-6776-5p ; hsa-mir-6861-5p ; hsa-mir-8084
Nearest miRNA
hsa-mir-128-1/Upstream/7491745; hsa-mir-10b/Downstream/1251848;
Nearest TSS
ENST00000437798/Upstream/9858; ENST00000637830/Downstream/100270;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/57469, chr2-CpG: 193/Downstream/565672
Upstream sequence
CTTATATACTAGATGTCCTATGTATCCAGTGGGTGATCATTTACTTGTATGTCAGATTGACAAAGTATTTTACCAGTCTTCTATTTGTTTGGAGACTACC
Downstream sequence
AGATACACACAAGATATGCCAGTGCTTACTATGGATTACATACAGTCCACTTCTCCTGGCTATTGACTGTTACCATATGTAATTCTGAGATTATCATTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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