Basic Information
VIS ID
TVIS44005147
Fusion event
HTLV-1-TSPAN5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
99411461/98490310 (Hg38)
End
99411461/98490310 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
TSPAN5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12113/Upstream/11189727; hsa-mir-1243/Downstream/507077;
Nearest TSS
ENST00000502981/Upstream/4778; ENST00000505408/Downstream/6054;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/228262, chr4-CpG: 97/Downstream/167681
Upstream sequence
GGGTAACAAAGACGATGATCTGAGCAACTCAGCAAAGCAAGCAACAAGCTAGCAAACATACCTATGCCCGAAATAGCAAAATAATCCCTCCCCCAAAGAC
Downstream sequence
AAAGAAGTATGATCCCAACTGTCAGGAGATTCCTAGATCATCTGCACTCTCTGGGTTTAATTTGGAGGATAAAAATTGGCTTCTCAGACAAACTCATTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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