Basic Information
VIS ID
TVIS44005159
Fusion event
HTLV-1-RHOBTB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
22871951/23014438 (Hg38)
End
22871951/23014438 (Hg38)
Orient
-
Location type
Intronic
Target gene
RHOBTB2
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-124-1/Upstream/769401; hsa-mir-10400/Downstream/1939358;
Nearest TSS
ENST00000518652/Upstream/6599; ENST00000501897/Downstream/4897;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/7363, chr8-CpG: 108/Downstream/53704
Nearest cancer related gene
RHOBTB2(TSG, No orient, 0)
Upstream sequence
GCAGACATGAGGTTTCACACACTCTCCCTTTTGTATCAGAGGCTGGTTCTGTTGGGAACTTTGACCCTACCTGTATCAGATTATGTCACGGGACATACGT
Downstream sequence
AGTTTGAAAAATCCTCTTAGGTAATTCCAATGTCCTCCTTCTCTTCCTACCCTACCCCGTTGAGCTCTTGCTGTCATCCCTGGGGTCCCCCTGGTGGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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