Basic Information
VIS ID
TVIS44005176
Fusion event
HTLV-1-RSU1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
16713947/16671948 (Hg38)
End
16713947/16671948 (Hg38)
Orient
+
Location type
Intronic
Target gene
RSU1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-409-3p ; hsa-mir-409-5p
Nearest miRNA
hsa-mir-1265/Upstream/2235287; hsa-mir-107/Downstream/1173159;
Nearest TSS
ENST00000439456/Upstream/149943; ENST00000497849/Downstream/145435;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/150228, chr10-CpG: 68/Downstream/145142
Upstream sequence
atctcctaaccttgtgatcgacccccctcggcctcccaaagtgctgggattacaggcatgagccaccatgcccggcTGGCTCAAAGGCTTTTAAGTGAGA
Downstream sequence
AATTGTATATCAGATAATCCAGGATTATCTTATTTTacagttttgcagttacttaaaaaggtaaatctggccagacgcggtggctcatgcctgtaatccc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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