Basic Information
VIS ID
TVIS44005200
Fusion event
HTLV-1-IKZF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
214012668/213147944 (Hg38)
End
214012668/213147944 (Hg38)
Orient
-
Location type
Intronic
Target gene
IKZF2
miRNAs that regulate target gene
hsa-mir-130b-5p ; hsa-mir-125b-5p ; hsa-mir-374a-5p ; hsa-mir-627-3p ; hsa-mir-633 ; hsa-mir-450b-5p ; hsa-mir-6805-5p ; hsa-mir-876-5p ; hsa-mir-1290 ; hsa-mir-3167 ; hsa-mir-5004-3p ; hsa-mir-506-5p ; hsa-mir-1260a ; hsa-mir-1260b ; hsa-mir-6083 ; hsa-mir-5096 ; hsa-mir-3926 ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-10b-3p ; hsa-mir-6869-5p ; hsa-mir-496 ; hsa-mir-942-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-376a-5p ; hsa-mir-3938 ; hsa-mir-6844 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5588-3p ; hsa-mir-6832-3p ; hsa-mir-3156-3p ; hsa-mir-188-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-4301 ; hsa-mir-1306-5p ; hsa-mir-7850-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-30e-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10b/Upstream/221608; hsa-mir-1244-1/Downstream/610123;
Nearest TSS
ENST00000437798/Upstream/132666; ENST00000604818/Downstream/685;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/314618, chr2-CpG: 39/Downstream/4082
Nearest cancer related gene
IKZF2(TSG, No orient, 0)
Upstream sequence
ATTCATTGTCACATAAGATGTAATTACTAACTTTGCTTTATACACGCAATGGCATGCATAGCCTTCAAACTGTAAGGTAATACATTTTTCCCTTAGAAAC
Downstream sequence
TATAAGGAAATATCATTTAGAAATATACAGTTGAATGAAATGATGAGAAGCCATAATCAACCCACAATAAAAAAAATTAACAAAACTTTATTATCTCAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate