Basic Information
VIS ID
TVIS44005202
Fusion event
HTLV-1-SYN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
33028988/32633002 (Hg38)
End
33028988/32633002 (Hg38)
Orient
+
Location type
Intronic
Target gene
SYN3
miRNAs that regulate target gene
hsa-mir-4792 ; hsa-mir-6807-5p ; hsa-mir-186-3p
Nearest miRNA
hsa-mir-1286/Upstream/1011471; hsa-let-7a-3/Downstream/803580;
Nearest TSS
ENST00000624155/Upstream/49702; ENST00000444982/Downstream/150175;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/157625, chr22-CpG: 81/Downstream/168392
Upstream sequence
TCGGGTAGTTATGGATAATAACACAAAGCCTGTCATTTGGCCAGCACTTGAGAATTTATatagtggtcaagcgtgttcattccgaagccacaacccatgg
Downstream sequence
gttctcacccggctccttcacatacaggctcatgacgttaggcaaattacttctccactctgaaccttggtttcctcatttaccaaatgggaggaataac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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